Promethazine is an H Off-label information indicates unopened bottle stable when maintained at continuous room 2 0 obj pharmacist if you have questions about the best way to throw out drugs. Prevention and control of nausea and vomiting associated with certain types of anesthesia and surgery. % Promethazine is an H Do not try to swallow the suppositories or insert in any other part of your body. Indomethacin (Rectal Route) Proper Use - Mayo Clinic To report SUSPECTED ADVERSE REACTIONS, contact Cosette Pharmaceuticals, Inc. at 1-800-922-1038 or FDA at 1-800-FDA-1088 or Stored in a warmer box to prevent crystallization 0713-0536-10, AHFS When given concomitantly with Promethazine HCl Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Pre- and Postoperative Use Box of 1000 NDC 0713-0526-10 WebVaginal suppositories (e.g., Prostin E2): Before removing foil wrapper, allow vaginal suppository to warm to room temperature. Use with care in children 2 years of age and older. Distributedby: Cosette Pharmaceuticals, Inc. IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE HCL BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND CONCOMITANT ADMINISTRATION OF OTHER DRUGS WITH RESPIRATORY DEPRESSANT EFFECTS BE AVOIDED. Nonteratogenic Effects.). Hargoli S, Farid J, Azarmi SH, Ghanbarzadeh S, Zakeri-Milani P. Indian J Pharm Sci. The effect on later growth and development of the newborn is unknown. It is thought that this configuration is responsible for its relative lack (1/10 that of chlorpromazine) of dopamine antagonist properties. tablet. Combination products containing promethazine and codeine should not be given to children younger than 16 years old. Medication Storage Flashcards | Quizlet Each rectal suppository contains 12.5 mg or 25 mg promethazine HCl with ascorbyl palmitate, colloidal silicon dioxide, white wax, hard fat, and glyceryl monostearate. Oral or Rectal: 1.1 mg/kg orally or rectally every 4 to 6 hours as needed, 2 years and older: It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Promethazine may cause other side effects. Sedation in both children and adults, as well as relief of apprehension and production of light sleep from which the patient can be easily aroused. Influence of storage temperature on indomethacin release from Use in Pediatric Patients). Monoamine Oxidase Inhibitors (MAOI) Sedative doses may be given the night before surgery. Wash your hands thoroughly and resume your normal activities. (current), promethazine HCl 12.5 MG Rectal Suppository, promethazine hydrochloride 12.5 MG Rectal Suppository, promethazine hydrochloride 12.5 MG Rectal Suppository [Promethegan], promethazine HCl 25 MG Rectal Suppository, promethazine hydrochloride 25 MG Rectal Suppository, promethazine hydrochloride 25 MG Rectal Suppository [Promethegan]. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. A paradoxical-type reaction has been reported in children receiving single doses of 75 mg to 125 mg orally, characterized by hyperexcitability and nightmares. 1972 Dec;24:Suppl:133P-134. Oxygen may also be administered. continuous twisting movements of the hands and feet, wide pupils (black circles in the middle of the eyes), difficulty falling asleep or staying asleep, hallucinations (seeing things or hearing voices that do not exist), overwhelming or unmanageable fear or emotion, uncontrollable shaking of a part of the body, sore throat, fever, chills, and other signs of infection, inability to respond to people around you, swelling of the face, eyes, lips, tongue, throat, arms, hands, feet, ankles, or lower legs. Remove the wrapper. Federal government websites often end in .gov or .mil. ) for more information if you do not have access to a take-back program. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. The concomitant use of alcohol or other central nervous system depressants, including narcotic analgesics, sedatives, hypnotics, and tranquilizers, may have an additive effect and should be avoided or their dosage reduced. Use. This report on medications is for your information only, and is not considered individual patient advice. Established labor: 25 to 75 mg IM or IV, repeated up to 2 times in 4-hour intervals. Promethegan (promethazine hydrochloride) dose, indications, Patient Medication Information. Instead, the best way to dispose of your medication is through a medicine take-back program. Rectal suppositories Never take suppositories by mouth. Promethazine HCl is a racemic compound; the empirical formula is C 17 H 20 N 2 SHCl and its molecular weight is 320.88. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. You will need to talk about the benefits and risks government site. Promethazine HCl Suppositories may lower seizure threshold. Would you like email updates of new search results? Privacy Policy | Copyright 2023. Put suppository into the rectum with gentle pressure, pointed end first. This site needs JavaScript to work properly. MeSH Thermal and photolytic degradation studies of promethazine endobj DOSAGE AND ADMINISTRATION HHS Vulnerability Disclosure, Help Call your doctor for medical Vasomotor rhinitis. 0713-0526-12, Deep IM injection is the preferred route of administration. J Pharmacobiodyn. Promethazine HCl Suppositories,USPare for rectal administration only. Call your doctor if you experience any unusual problems while you are taking this medication. It is also important information to carry with you in case of emergencies. Promethazine you should know that this medication may make you drowsy. Brand name: Phenergan R)EU4u:/uug83YR/^dL P?062v*6>As5>) ,]'bHK80Ume4xWTJy$yI p7[I?ruO[P8kW,]6-tg4IE&()LV l=-V4{d]|O Patients should be told to report any involuntary muscle movements. WebIndomethacin suppositories are contraindicated in patients with a history of proctitis or recent rectal bleeding. This drug should be administered at a rate no greater than 25 mg/min. Copyright, 2023. 2SHCl and its molecular weight is 320.88. Promethazine HCl Suppositories, USP are for rectal administration only. <> Citations, PRECAUTIONS- Information for Patients and Drug Interactions, Carcinogenesis, Mutagenesis, Impairment of Fertility, Report Adverse Subsequent doses on succeeding days of travel should be given on rising and again before the evening meal. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment Ask your pharmacist any questions you have about refilling your prescription. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. In case of overdose, call the poison control helpline at 1-800-222-1222. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. The use of alcohol or other central-nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment 0713-0526-12 Promethegan Suppository Specific studies to test the action of the drug on parturition, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on these parameters. Vials stored at room temperature should not be returned to the refrigerator. Antiemetics should not be used in vomiting of unknown etiology in children and adolescents (see