The absence of a bacteriostat in sterile water only allows for a one time use. Water for Injection, USP is chemically designated H2O. RxList does not provide medical advice, diagnosis or treatment. Peptide Reconstitution: Dosing, Mixing and Storage Guidelines Withdraw approximately 1mL of bacteriostatic water from the vial and slowly transfer it into the peptide container. The dosage and administration schedule should follow applicable recommendations [18, 19]. PDF SOLU-MEDROL (methylprednisolone sodium succinate) Label - Food and Drug Which one to choose: Bacteriostatic Water vs. Sterile Water. Often available as a lyophilized powder, hCG is best reconstituted with bacteriostatic water for injection due to the solvents efficiency and preservative agents. Reconstitution means any Securitization Transaction or Whole Loan Transfer. Do not use unless the solution is clear and seal intact. Mrose . The volume of the preparation to be used for diluting or dissolving any drug for injection is dependent on the vehicle concentration, dose and route of administration as recommended by the manufacturer. See PRECAUTIONS. What is the difference between bacteriostatic water and sterile water We spent 20 hours of research finding optimal recommended dosages for every popular peptide. For more information, please see our These Terms will be applied fully and affect to your use of this Website. When diluting or dissolving drugs, mix thoroughly and use promptly. Composed of sterile water and 0.9% benzyl alcohol and an organic preservative agent, bacteriostatic water resists bacterial growth and contamination [1]. To the extent that Peptides.org references a product that is also a prescription medication, Peptides.org does not does not offer medical diagnosis or treatment advice. IMPORTANT Use only the accompanying diluent or Bacteriostatic Water For Injection with. Reconstitute Definition & Meaning - Merriam-Webster If both items are the same (benzyl alcohol bacteriostatic solutions) why use the different name? Call your doctor for medical advice about side effects. He is responsible for ensuring the quality of the information presented on our website. Because there is 1ml of bacteriostatic water, this means that we need to mix 5000mcg with 1ml of bacteriostatic water. It depends on the compound, there is no universal conversion, About: Muscle and Brawn is a coaching company specializing in bodybuilding, hormones, peptides, anabolics, and other biohacking. For safe storage, adhere to manufacturer indications. One vial of BPC 157 contains 5mg, which also means 5000mcg. Insert your needle tip into the sealed bottle of bacteriostatic water. Although rarely, but they can occur, those side effects are more related to the drug that is dissolved in the bacteriostatic water. Water is an essential constituent of all body tissues and accounts for approximately 70% of total body weight. Bacteriostatic Water belongs to a class of drugs called Sterile Irrigating Solutions. With our easy-to-use reconstitution calculator, you now dont have to worry about all the multiplication, division or the unit conversion and all. Should I dilute with sterile water (USP grade) or BW? The re-use of sterile water for injections is strictly prohibited. It would seem very difficult for a manufacturer to be able to demonstrate satisfactory validation of sterilization of a lyophilizer by chemical "treatment.". Your access to Peptides.org is subject to our full disclaimer and terms of use. Bacteriostatic Water for Injections | The A-Z Guide, Add a header to begin generating the table of contents. It is a copolymer of ethylene and propylene. Last updated on Dec 1, 2022. if a dosage is say 20mcg of each individually, wht is a dosage of the mix? This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. swelling of your face, lips, tongue, or throat, redness, warmth, and pain at the injection site, tenderness or irritation at the injection site. Slowly extract the bacteriostatic water until the solution reaches your desired level. Although adverse reactions to intravenous, intramuscular or subcutaneous injection of 0.9% benzyl alcohol are not known to occur in man, experimental studies of small volume parenteral preparations containing 0.9% benzyl alcohol in several species of animals have indicated that an estimated intravenous dose up to 30 mL may be safely given to an adult without toxic effects. Home > Peptides > Peptide Reconstitution + Mixing Guide with Calculator. How many mL are required for one dose? Before really going straight into the topic, lets first understand the need for the phrase reconstituting peptides. Distilled water is a form of sterile water but sterile water is not always distilled! Bacteriostatic Water is available generically and has the same name. These are not all the possible side effects of Bacteriostatic Water. (I would personally recommend bacteriostatic water because of its longer shelf-life). BACTERIOSTATIC 0.9% SODIUM CHLORIDE INJECTION, USP 10mL VIAL SOLU-CORTEF Dosage and Administration (hydrocortisone sodium succinate tion ()r-kn (t)-st-t (y)-shn. A major concern with the filling operation is assurance of fill volumes. Each milliliter (mL) contains sodium chloride 9 mg and 0.9% (9 mg/mL) benzyl alcohol added as a bacteriostatic preservative. AOD 9604 can either be reconstituted in bacteriostatic water (BAC) or sterile water. Providing a method for introducing the sterile moisture with uniformity may be difficult. Short-term storage can be done at 4C, while long-term storage can be done by freezing at -20C or -80C, or by lyophilization. Verified Purchase. Before digging deeper into precise conditions required to store peptides, you should know that keeping a peptide vial away from intense light, high temperature and moisture is a MUST. Consult with pharmacist, if available. Other side effects from bacteriostatic water have been reported to include tissue death, venous thrombosis, infection at the injection site, fever, abscess formation as well as a febrile response. Follow medical advice and relevant indications for maximum safety and results when using bacteriostatic water for injections. These include subcutaneous, intramuscular, intravenous, and intradermal injection routes [. Lysis is the breaking down of a cell or membrane. In order to provide guidance and information to investigators, some industry procedures and deficiencies associated with lyophilized products are identified in this ITG. First, lets break down the basics of sterile water. Due to the potential toxicity of benzyl alcohol in neonates, solutions containing benzyl alcohol must not be used in this patient population. Recommended dosage guidelines are usually based on either the clinical trials or the efficacy of the peptide. Many people have this mentality that bacteriostatic water and sterile water are the same thing, and that can bring disastrous results. Dont just shoot the water like a spray or something. See WARNINGS, PRECAUTIONS Because it is vulnerable to contamination, it is sold in single-dose containers [5]. While most of the peptides will be soluble in bacteriostatic water and sterile water, some really wont, and this will be depending on the polarity of the peptides. On the insulin syringe, 100 units correspond to 1ml, so 10 units will correspond to 0.1ml of the bacteriostatic water. Carefully install the needle tip on a syringe. Though their features overlap, bacteriostatic water and sterile water have several significant differences. There have been times when sterile water has been in short supply. Management of Drug Shortages with 0.9% Sodium Chloride, Sterile Water Bacteriostatic water should not be used on individuals with benzyl alcohol allergies. The container requires no vapor barrier to maintain the proper labeled volume. Bacteriostatic 0.9% Sodium Chloride Injection, USP is a sterile, nonpyrogenic, isotonic solution of sodium chloride in water for injection. Click to reveal But not all peptides dissolve in water easily, so it usually is recommended that you try to dissolve the peptide in any of these waters using Sonication. The small volume of fluid provided by Bacteriostatic Water for Injection, USP when used only as a pharmaceutic aid for diluting or dissolving drugs for parenteral injection, is unlikely to exert a significant effect on fluid balance except possibly in very small infants. This parenteral preparation is indicated only for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Due to the lack of antimicrobials, sterile water can easily be contaminated once exposed to surroundings and even yourself. It is essential to avoid exposure to light and high temperatures, which can lead to peptide degradation. LTD.Salt Lake Electronics ComplexEP Block, Sector V, BidhannagarKolkata, West Bengal 700091, INDIA. In order to reconstitute 10 equal dosages, we need to mix 1ml of bacteriostatic water in all the 10 injections, which means 0.1ml of water per dosage. We do the complete research and follow standards before starting the manufacturing process. The reconstitution process is the same for both. You will learn its various applications, how it differs from sterile water, and your best online source to buy bacteriostatic water kits. This discussion will address some of the problems associated with the manufacture and control of a lyophilized dosage form. Stability data should be reviewed and the justification of the expiration date should be based on batches with the higher moisture content. Buckle LLC reserves the right to remove any of Your Content from this Website at any time without notice. Its preservative content reduces the risk of contamination and infection, boosts shelf life, and enables optimal solvency for aqueous injection [6]. This can come into play when preparing for traveling, budgeting monthly expenses and storage. Ob es sich um die Verwaltung von Kundeninvestitionen oder einen umfassenden Plan fr sie zu schaffen und ihre Familie sind unsere zertifizierten Planern gewidmet mit einem auergewhnlichen Service zu bieten. What is the difference between bacteriostatic water vs. sterile water for injection? Cookie Notice Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) of benzyl alcohol added as a bacteriostatic preservative. Bacteriostatic Water for Injection, USP is a sterile, nonpyrogenic preparation of water for injection containing 0.9% (9 mg/mL) or 1.1% (11 mg/mL) benzyl alcohol added as a bacteriostatic preservative. Allow the powder to naturally dissolve until the vial is transparent. Selective Estrogen Receptor Modulator (SERM), Induction of Ovulation with CLOMIMED 50 (Clomiphene Citrate), Anemia in Cancer Patients: treatment with DECAMED 250 (Nandrolone Decanoate), PROVIMED 25 (Mesterolone) for the Treatment of Male Infertility. Sterile water is available for injection use such as intravenous, intramuscular and subcutaneous. The choice is purely up to the user which solution to use. 3) Choose the size of the syringe you want . Shortage of sterile water and reconstitution of omalizumab