Our present findings confirmed these factors and identified other risk factors, including advanced disease, serous histology, and the presence of malignant ascites. Risk factors for these reactions included advanced disease, serous histological type, malignant ascites, and history of drug allergies. Annals of Oncology (2021) 32 (suppl_5): S407-S446. Table 2. Cancer. eCollection 2022 Apr. The ESMO Clinical Practice Guidelines, prepared and reviewed by leading experts and based on the findings of evidence-based medicine, provide you with a set of recommendations to help patients with the best care options. Skin Testing and Basophil Activation Testing Is Useful for Assessing Immediate Reactions to Polyethylene Glycol-Containing Vaccines. Oncol Res Treat. eCollection 2022. Evaluating whether any factors can predict carboplatin hypersensitivity, we identified a high correlation with the carboplatin cycle and cumulative dose (Pearson correlation coefficient 0.9318). 107, 163165. This site uses cookies. Merck: Driving Innovation in Cancer Care at ESMO 2017 With New Data in Desensitization treatment with cisplatin after carboplatin hypersensitivity reaction in gynecologic cancer. Expert Opin Drug Saf (2003) 2(6):597607.10.1517/14740338.2.6.597 Careers. Please enable it to take advantage of the complete set of features! eCollection 2022. Hypersensitivity reactions to carboplatin administration are common but not always severe: a 10-year experience. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. de Las Vecillas Snchez L, Alenazy LA, Garcia-Neuer M, Castells MC. The MASCC/ESMO guidelines recommend that patients receiving HEC are given a dose of 20 mg dexamethasone on Day 1 to prevent acute emesis; however, if the NK 1 RAs aprepitant or netupitant are also used, a reduced dose of 12 mg dexamethasone is recommended. These recommendations aim to develop guidance to mitigate the negative effects of the COVID-19 pandemic on the diagnosis and treatment of cancer patients. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. (Moon et al., 2013) BRCA1/2 mutation patients had early-onset carboplatin hypersensitivity at a lower cumulative exposure. doi: 10.1200/JCO.1999.17.4.1141, Moon, D. H., Lee, J. M., Noonan, A. M., Annunziata, C. M., Minasian, L., Houston, N., et al. Educate. ESMO 2017 was held in partnership with the European Association for Cancer Research (EACR) in Madrid . J. Med. 66, 730. Abstracts, slide sets and webcasts from ESMO 2017 Congress are now available. Cardiopulmonary resuscitation and endotracheal intubation were performed, but the patient finally expired due to respiratory failure. Int J Med Sci (2011) 8(4):3328.10.7150/ijms.8.332 Nitipir C, Parosanu A, Popa AM, Cotan H, Olaru M, Iaciu C, Orlov Slavu C. Cureus. Management of uncommon chemotherapy-induced emergencies. Newly diagnosed and relapsed epithelial ovarian carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Cumulative incidence of carboplatin-related hypersensitivity reactions according to the carboplatin administration cycle number (A) and carboplatin dose (B). Patients should be observed closely for hypersensitivity reactions for a minimum of 30 minutes following each IV iron . Bayer to Highlight New Research at ESMO 2017 Congress - PR Newswire However, 48 (78.7%) of these patients developed repeated hypersensitivity reactions, even after pre-treatment with intravenous antihistamines, H2 blocker, and corticosteroids prior to carboplatin re-administration. However, prolonged carboplatin use is associated with an increased incidence of carboplatin-related hypersensitivity reactions (Markman et al., 1999; Wang et al., 2009). (2009). (2015). Oncol. Clinical analysis of thirteen cases of hypersensitivity reactions to carboplatin. 57 . 1; Mandac Smoljanovi, Inga 2. Diagnoses and Management of Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: Reactions to Taxanes and Monoclonal Antibodies. 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