Anbalagan, K. and Sadique, J. Its scientific name is Withania somnifera Dunal, and it belongs to a class of herbs called rasayana, praised for their revitalizing effects on health. Ashwagandha has mild interactions with at least 29 different drugs. By Mayo Clinic Staff Herbal supplements are natural, so they must be safe, right? This is because ashwagandha is thought to be an adaptogen, a substance that may help the body resist stress. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults: A double-blind, randomized, placebo-controlled clinical study. Malviya, N., Jain, S., Gupta, V. B., and Vyas, S. Recent studies on aphrodisiac herbs for the management of male sexual dysfunction--a review. hydrochlorothiazide, spironolactone, chlorthalidone). Ashwagandha is not naturally found in foods, which means the only way to get it is through supplements. 2019;11(12):e6466. Supplements That Are Similar to Ashwagandha. Moreover, researchers also noted several limitations of the studies included, such as the varying methods used to assess sleep quantity and quality. Some other sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others. 1996;35(1):95-100. Ashwagandha has not been well studied in regard to potential interactions with prescription medication. Talk with a healthcare provider about which herb or supplement may be best for you. What Vitamins Can You Not Take With Anti-Depressants? In rare cases, ashwagandha may cause liver damage. Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. Suryawanshi G, Abdallah M, Thomson M, Desai N, Chauhan A, Lim N. Ashwagandha-Associated Acute Liver Failure Requiring Liver Transplantation. Kaur, K., Rani, G., Widodo, N., Nagpal, A., Taira, K., Kaul, S. C., and Wadhwa, R. Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha. These are: In addition to these commonly prescribed antidepressants, there are other central nervous system drugs with antidepressant effects, like antipsychotics, as well as herbs and supplements that have natural antidepressant properties. The concern would be blood pressure drops too lowif combining high blood pressure medications and ashwagandha. The combination could decrease the effectiveness of these medications. What Happens If I Take Too Much Ashwagandha? Biogerontology. View abstract. View abstract. Byetta, Trulicity, Ozempic, Rybelsus, Bydureron, Victoza, Mounjaro), Sulfonylureas (e.g. View abstract. Withania somnifera, also commonly as ashwagandha or winter cherry, is a shrub native to parts of Asia and Africa. Benefits of Ashwagandha and How Much To Take - Cleveland Clinic What are some herbs that are contraindicated with Cotellic (cobimetinib)? Ashwagandha contains several active constituents including: The mechanism of how ashwagandha works, for all of its purported benefits, is not well understood. Ashwagandha has no known moderate interactions with any drugs. Medically reviewed by Drugs.com. Does Ashwagandha Interact With Any Medications? ; Vomiting and nausea. Be sure to tell your doctor that you take this product if you are scheduled for surgery or tests. Essential vitamins, minerals and amino acids that are involved in neurobiological function include: However, several of these have had mixed results in helping support depression treatment. Baker C, Kirby JB, O'Connor J, Lindsay KG, Hutchins A, Harris M. The perceived impact of ashwagandha on stress, sleep quality, energy, and mental clarity for college students: qualitative analysis of a double-blind randomized control trial. The best time to take ashwagandha is at the time that works best for you. This interference is likely due to a similarity in chemical structure, according to Drugs.com. Upadhaya L and et al. Be sure to confirm new supplements fit your dietary needs or preferences. This information does not endorse any treatments or medications as safe, effective, or approved for treating a specific patient. When to Take Ashwagandha: Morning or Night? - Healthy Directions Significant improvements were seen in all sleep parameters for those who took ashwagandha (300 milligrams twice daily). According to the Cleveland Clinic, there are six different types of medications commonly used to treat depression. 2004;42(12):2015-2020. Its effect on arterial blood pressure in anaesthetized dogs. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Take extra care and check with your doctor if you have: Signs of a very bad reaction. National Library of Medicines list You may think that these supplements are safe because they also have antidepressant effects, but it's not that simple. View abstract. Take extra care if you are taking iron supplements. Does Ambien Cause Withdrawal Symptoms After Stopping? View abstract. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. Can Ashwagandha and SSRI be taken together? - iCliniq As a general rule of thumb, never exceed the recommended dose of ashwagandha. Ashwagandha is thought to have a positive impact on chronic stress. ashwaganda: Dosing, contraindications, side effects, and pill pictures - epocrates online Drug Lookup: Browse: Drugs Alt Meds Select a medication above to begin. Some research has proven that this may indeed be true. However, if you were to combine St. John's wort with antidepressants like SSRIs, you could end up with disastrous results. 2020;12(4):1119. Cancer Lett. Ashwagandha has mild interactions with at least 29 different drugs. Take ashwagandha with these drugs only under your doctor's supervision, recommends the Langone Medical Center at New York University. Ashwagandha interacts with 623 drugs. Ashwagandha is purported as useful for relieving stress, fatigue, pain and gastrointestinal problems, and treating diabetes, rheumatoid arthritis and epilepsy. Tohda, C. [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]. It is commonly used for stress. What to Look for When Choosing Ashwagandha Supplements, Uses of Lavender: Everything You Need to Know, I Tried Taking Ashwagandha and It Gave Me Crazy Vivid Dreams, Natural withanolides in the treatment of chronic diseases, Pharmacological evaluation of ashwagandha highlighting its healthcare claims, safety, and toxicity aspects, Potential clinical applications of Ashwagandha (, Adaptogenic and anxiolytic effects of Ashwagandha root extract in healthy adults: a double-blind, randomized, placebo-controlled clinical study, An investigation into the stress-relieving and pharmacological actions of an ashwagandha (, An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (, Efficacy and safety of Ashwagandha root extract on cognitive functions in healthy, stressed adults: a randomized, double-blind, placebo-controlled study, A double-blind, randomized, placebo-controlled trial on the effect of Ashwagandha (, Safety of ashwagandha root extract: a randomized, placebo-controlled, study in healthy volunteers, Ashwagandha-induced liver injury: a case series from Iceland and the US Drug-Induced Liver Injury Network, DNA damage by withanone as a potential cause of liver toxicity observed for herbal products of, Effects of L-Theanine administration on stress-related symptoms and cognitive functions in healthy adults: a randomized controlled trial, Vitamin D supplementation improves anxiety but not depression symptoms in patients with vitamin D deficiency, Vitamin E, turmeric and saffron in treatment of Alzheimer's disease, Tart cherry juice in athletes: a literature review and commentary, Dietary supplements: what you need to know.